Chronic Stress Contributes to Cognitive Dysfunction and Hippocampal Metabolic Abnormalities in APP/PS1 Mice.

@article{Han2017ChronicSC,
  title={Chronic Stress Contributes to Cognitive Dysfunction and Hippocampal Metabolic Abnormalities in APP/PS1 Mice.},
  author={Bing Han and Jin-Hua Wang and Yuan yuan Geng and Li Shen and Hua-Long Wang and Yan-yong Wang and Ming-wei Wang},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2017},
  volume={41 5},
  pages={
          1766-1776
        }
}
BACKGROUND/AIMS Stress response is determined by the brain, and the brain is a sensitive target for stress. Our previous experiments have confirmed that once the stress response is beyond the tolerable limit of the brain, particularly that of the hippocampus, it will have deleterious effects on hippocampal structure and function; however, the metabolic mechanisms for this are not well understood. METHODS Here, we used morris water maze, elisa and gas chromatography-time of flight/mass… CONTINUE READING

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