Chronic Restraint Stress Promotes Lymphocyte Apoptosis by Modulating Cd95 Expression

@article{Yin2000ChronicRS,
  title={Chronic Restraint Stress Promotes Lymphocyte Apoptosis by Modulating Cd95 Expression},
  author={Deling Yin and David Tuthill and Richard A Mufson and Yufang Shi},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={191},
  pages={1423 - 1428}
}
Depending on the duration and severity, psychological tension and physical stress can enhance or suppress the immune system in both humans and animals. Although it is well established that stress alters the release of various hormones and neurotransmitters, the mechanisms by which stress affects immune responses remain elusive. We report here that mice subjected to chronic 12-hour daily physical restraint for two days exhibited a significant reduction in splenocytes, a process likely mediated… CONTINUE READING
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