Chronic Rejection Pathology after Orthotopic Lung Transplantation in Mice: The Development of a Murine BOS Model and Its Drawbacks

@inproceedings{Vleeschauwer2012ChronicRP,
  title={Chronic Rejection Pathology after Orthotopic Lung Transplantation in Mice: The Development of a Murine BOS Model and Its Drawbacks},
  author={St{\'e}phanie I De Vleeschauwer and Wolfgang Jungraithmayr and Shana Wauters and Stijn Willems and Manuela Rinaldi and Annemie Vaneylen and Stijn Verleden and Anna Willems-Widyastuti and Ken R Bracke and Guy Brusselle and Erik K. Verbeken and Dirk E Van Raemdonck and Geert Verleden and Bart Vanaudenaerde},
  booktitle={PloS one},
  year={2012}
}
Almost all animal models for chronic rejection (CR) after lung transplantation (LTx) fail to resemble the human situation. It was our attempt to develop a representative model of CR in mice. Orthotopic LTx was performed in allografts receiving daily immunosuppression with steroids and cyclosporine. Controls included isografts and mice only undergoing thoracotomy (SHAM). Allografts were sacrificed 2, 4, 6, 8, 10 or 12 weeks after LTx. Pulmonary function was measured repeatedly in the 12w… CONTINUE READING
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