Chronic Pseudomonas aeruginosa lung infection in normal and athymic rats.

  title={Chronic Pseudomonas aeruginosa lung infection in normal and athymic rats.},
  author={Helle Krogh Johansen and Frank Espersen and Svend Stenvang Pedersen and Hans Petter Hougen and J\orgen Rygaard and Niels H\oiby},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  volume={101 3},
We have compared a chronic lung infection with Pseudomonas aeruginosa embedded in alginate beads in normal and athymic rats with an acute infection with free live P. aeruginosa bacteria. The following parameters were observed and described: mortality, macroscopic and microscopic pathologic changes, and antibody responses. The rats challenged with P. aeruginosa alginate beads experienced a generally more severe lung pathology and the antibody responses were more homogeneous with less dispersion… CONTINUE READING

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