Chronic Peptide Therapy With B-Type Natriuretic Peptide in Patients With Pre-Clinical Diastolic Dysfunction (Stage B Heart Failure).

@article{Wan2016ChronicPT,
  title={Chronic Peptide Therapy With B-Type Natriuretic Peptide in Patients With Pre-Clinical Diastolic Dysfunction (Stage B Heart Failure).},
  author={Siu-fung. Wan and Paul M McKie and John A. Schirger and Joshua P. Slusser and David Hodge and Margaret May Redfield and John C Jr. Burnett and Horng Haur Chen},
  journal={JACC. Heart failure},
  year={2016},
  volume={4 7},
  pages={
          539-547
        }
}
OBJECTIVES This study determined whether there is development of tachyphylaxis to enhancement of cardiorenal response to acute volume loading (AVL) with B-type natriuretic peptide (BNP) after 12-week, twice-daily subcutaneous BNP administration in patients with preclinical diastolic dysfunction (PDD). BACKGROUND PDD is characterized by normal systolic function and moderate or severe diastolic dysfunction but no symptoms of heart failure (HF). Impairment in cardiorenal endocrine response to… CONTINUE READING
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