Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis.

@article{Langston1983ChronicPI,
  title={Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis.},
  author={J. Langston and P. Ballard and J. Tetrud and I. Irwin},
  journal={Science},
  year={1983},
  volume={219 4587},
  pages={
          979-80
        }
}
Four persons developed marked parkinsonism after using an illicit drug intravenously. Analysis of the substance injected by two of these patients revealed primarily 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) with trace amounts of 1-methyl-4-phenyl-4-propionoxy-piperidine (MPPP). On the basis of the striking parkinsonian features observed in our patients, and additional pathological data from one previously reported case, it is proposed that this chemical selectively damages cells in… Expand

Paper Mentions

Pattern of dopaminergic loss in the striatum of humans with parkinsonism induced by MPTP
  • G. Sawle
  • Medicine
  • Journal of neurology, neurosurgery, and psychiatry
  • 2000
A sheep model for MPTP induced Parkinson-like symptoms.
...
1
2
3
4
5
...

References

SHOWING 1-3 OF 3 REFERENCES
APRAXIA OF LID OPENING.
Piperidine derivatives; 4-arylpiperidines.