Chronic Obstructive Pulmonary Disease-Derived Circulating Cells Release IL-18 and IL-33 under Ultrafine Particulate Matter Exposure in a Caspase-1/8-Independent Manner

@article{DeFalco2017ChronicOP,
  title={Chronic Obstructive Pulmonary Disease-Derived Circulating Cells Release IL-18 and IL-33 under Ultrafine Particulate Matter Exposure in a Caspase-1/8-Independent Manner},
  author={Gianluigi De Falco and Chiara Colarusso and Michela Terlizzi and Ada Popolo and Michela Pecoraro and Mario Commodo and Patrizia Minutolo and Mariano Sirignano and Andrea D’Anna and R P Aquino and Aldo Pinto and Antonio Molino and Rosalinda Sorrentino},
  journal={Frontiers in Immunology},
  year={2017},
  volume={8}
}
Chronic obstructive pulmonary disease (COPD) is considered the fourth-leading causes of death worldwide; COPD is caused by inhalation of noxious indoor and outdoor particles, especially cigarette smoke that represents the first risk factor for this respiratory disorder. To mimic the effects of particulate matter on COPD, we isolated peripheral blood mononuclear cells (PBMCs) and treated them with combustion-generated ultrafine particles (UFPs) obtained from two different fuel mixtures, namely… 
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