Chronic Nicotine Differentially Regulates 6-and 3-Containing Nicotinic Cholinergic Receptors in Rat Brain

@inproceedings{Perry2007ChronicND,
  title={Chronic Nicotine Differentially Regulates 6-and 3-Containing Nicotinic Cholinergic Receptors in Rat Brain},
  author={David C. Perry and Danyan Mao and Allison B. Gold and John McIntosh and John Christopher Pezzullo and Kenneth J. Kellar},
  year={2007}
}
We investigated the effects of chronic nicotine on 6and 3-containing nicotinic acetylcholine receptors (nAChRs) in two rat brain regions using three methodological approaches: radioligand binding, immunoprecipitation, and nicotine-stimulated synaptosomal release of dopamine. Nicotine was administered by osmotic minipumps for 2 weeks. Quantitative autoradiography with [I] -conotoxin MII to selectively label 6* nAChRs showed a 28% decrease in binding in the striatum but no change in the superior… CONTINUE READING

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