Chronic Necrotizing Bronchopulmonary Aspergillosis With Elements of Bronchocentric Granulomatosis


Chronic necrotizing pulmonary aspergillosis (CNPA) is an unusual form of pulmonary aspergillosis arising in the setting of mildly immune compromised state or altered local defense system. CNPA rarely shows histological findings mimicking bronchocentric granulomatosis (BCG), which is characterized by peribronchiolar granulomatous destruction. We describe a case representing CNPA with elements of BCG. A-64 year-old woman was admitted because of atypical pneumonia with multi-focal variable sized consolidations and cavitary lesions on high-resolution computed tomography (HRCT). The open lung biopsy specimen showed large areas of necrotizing pneumonia with some scattered aspergillus hyphae within the lung parenchyma. Some terminal bronchioles were found to be destroyed and were replaced by peribronchiolar granulomatous inflammation. There was no evidence of angioinvasion by aspergillus or aspergillous emboli. Despite vigorous antifungal agent and steroid treatment, she died of acute airway obstruction by bronchial casts on the thirty-fourth hospital day.

Extracted Key Phrases

1 Figure or Table


Citations per Year

70 Citations

Semantic Scholar estimates that this publication has 70 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@inproceedings{Kim2002ChronicNB, title={Chronic Necrotizing Bronchopulmonary Aspergillosis With Elements of Bronchocentric Granulomatosis}, author={Doh Hyung Kim and Jae Hyun Lee and Byung Ha Kim and Eun Kyung Choi and Jae Seok Park and Keun youl Kim and Young Hi Choi and Na Hye Myong and Kye Young Lee}, booktitle={The Korean journal of internal medicine}, year={2002} }