Chronic NF-{kappa}B blockade reduces cytosolic and mitochondrial oxidative stress and attenuates renal injury and hypertension in SHR.

@article{Elks2009ChronicNB,
  title={Chronic NF-\{kappa\}B blockade reduces cytosolic and mitochondrial oxidative stress and attenuates renal injury and hypertension in SHR.},
  author={Carrie M Elks and Nithya Mariappan and Masudul Haque and Anuradha Guggilam and Dewan Syed Abdul Majid and Joseph Francis},
  journal={American journal of physiology. Renal physiology},
  year={2009},
  volume={296 2},
  pages={F298-305}
}
Nuclear factor-kappaB (NF-kappaB) plays an important role in hypertensive renal injury; however, its roles in perpetuating mitochondrial oxidative stress and renal dysfunction remain unclear. In this study, we assessed the effects of chronic NF-kappaB blockade with pyrrolidine dithiocarbamate (PDTC) on renal dysfunction and mitochondrial redox status in spontaneously hypertensive rats (SHR). PDTC (150 mg.kg body wt(-1).day(-1)) or vehicle was administered orally to 8-wk-old SHR and their… CONTINUE READING

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