Chronic N-methyl-D-aspartate administration increases the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat.

@article{Lee2008ChronicNA,
  title={Chronic N-methyl-D-aspartate administration increases the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat.},
  author={Ho-joo Lee and Jagadeesh Sridhara Rao and Lisa Chang and Stanley I. Rapoport and Richard P. Bazinet},
  journal={Journal of lipid research},
  year={2008},
  volume={49 1},
  pages={162-8}
}
Whereas antibipolar drug administration to rats reduces brain arachidonic acid turnover, excessive N-methyl-d-aspartate (NMDA) signaling is thought to contribute to bipolar disorder symptoms and may increase arachidonic acid turnover in rat brain phospholipids. To determine whether chronic NMDA would increase brain arachidonic acid turnover, rats were daily administered NMDA (25 mg/kg, ip) or vehicle for 21 days. In unanesthetized rats, on day 21, [1-(14)C]arachidonic acid was infused… CONTINUE READING
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