Chronic N(G)-nitro-L-arginine methyl ester-induced hypertension : novel molecular adaptation to systolic load in absence of hypertrophy.

@article{Bartunek2000ChronicNM,
  title={Chronic N(G)-nitro-L-arginine methyl ester-induced hypertension : novel molecular adaptation to systolic load in absence of hypertrophy.},
  author={Jozef J. Bartunek and Ellen O. Weinberg and Minori Tajima and Susanne Rohrbach and Sarah E Katz and Pamela Sylvia Douglas and Beverly H. Lorell},
  journal={Circulation},
  year={2000},
  volume={101 4},
  pages={423-9}
}
BACKGROUND Chronic N(G)-nitro-L-arginine methyl ester (L-NAME), which inhibits nitric oxide synthesis, causes hypertension and would therefore be expected to induce robust cardiac hypertrophy. However, L-NAME has negative metabolic effects on protein synthesis that suppress the increase in left ventricular (LV) mass in response to sustained pressure overload. In the present study, we used L-NAME-induced hypertension to test the hypothesis that adaptation to pressure overload occurs even when… CONTINUE READING

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