Chronic Myelomonocytic Leukemia With Fibrosis Is a Distinct Disease Subset With Myeloproliferative Features and Frequent JAK2 p.V617F Mutations

@article{Gur2018ChronicML,
  title={Chronic Myelomonocytic Leukemia With Fibrosis Is a Distinct Disease Subset With Myeloproliferative Features and Frequent JAK2 p.V617F Mutations},
  author={Hatice Deniz Gur and Sanam Loghavi and Guillermo Garcia-Manero and Mark J. Routbort and Rashmi Kanagal‐Shamanna and Andr{\'e}s E Quesada and Haitham Khogeer and Sherry A. Pierce and L Jeffrey Medeiros and Hagop M Kantarjian and Joseph D. Khoury},
  journal={The American Journal of Surgical Pathology},
  year={2018},
  volume={42},
  pages={799–806}
}
  • Hatice Deniz Gur, Sanam Loghavi, +8 authors Joseph D. Khoury
  • Published in
    The American journal of…
    2018
  • Medicine
  • The American Journal of Surgical Pathology
  • A subset of patients with chronic myelomonocytic leukemia (CMML) presents with significance myelofibrosis. In myelodysplastic syndromes, significant myelofibrosis has been associated with adverse outcomes and p53 dysregulation. However, in CMML the clinical and molecular correlates of significant myelofibrosis at presentation remain poorly understood. From a cohort of 651 CMML patients, we identified retrospectively 20 (3.1%) cases with moderate to severe reticulin fibrosis (CMML-F) detected at… CONTINUE READING

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