Chronic Myelogenous Leukemia: Biology and Therapy

  title={Chronic Myelogenous Leukemia: Biology and Therapy},
  author={S. Faderl and M. Talpaz and Z. Estrov and H. Kantarjian},
  journal={Annals of Internal Medicine},
  • S. Faderl, M. Talpaz, +1 author H. Kantarjian
  • Published 1999
  • Medicine
  • Annals of Internal Medicine
  • Chronic myelogenous leukemia is a myeloproliferative disorder with clonal expansion of transformed primitive hematopoietic progenitor cells (1). It is characterized by a biphasicor triphasic clinical course in which a terminal blastic phase follows achronic phase of variable duration. The cytogenetic hallmark of chronicmyelogenous leukemia is the Philadelphia chromosome (Ph), a shortened chromosome 22 resulting from a translocation between the long arms of chromosome 9 and 22, t(9; 22)(q34; q11… CONTINUE READING
    330 Citations

    Paper Mentions

    Interventional Clinical Trial
    A randomized, open-label assessor blinded, multi-center, controlled phase II Trial to evaluate the efficacy of AOP2014 administered bi-weekly subcutaneously (s.c.) in preventing… Expand
    ConditionsChronic Myeloid Leukemia in Remission
    InterventionDrug, Other
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