Chronic Lyme disease: in defense of the scientific enterprise
@article{Baker2010ChronicLD, title={Chronic Lyme disease: in defense of the scientific enterprise}, author={Phillip J. Baker}, journal={The FASEB Journal}, year={2010}, volume={24}, pages={4175 - 4177} }
There is no better example of a relentless attack on evidence‐based biomedical research and the integrity of outstanding scientists than that associated with the treatment of a poorly defined condition called “chronic Lyme disease.” Here, a scientifically naive general population, the lay press, and legislators, who in most instances are unable to evaluate and judge scientific evidence properly, have been misled by patient advocate groups to believe that extended antibiotic therapy is the best…
17 Citations
The Lyme disease chronicles, continued: Chronic Lyme disease: in defense of the patient enterprise
- Medicine
- 2010
In his attack on “Lyme disease activists” who have besmirched the “scientific enterprise,” Phillip Baker misrepresents the controversy over tick-borne diseases and cites a long list of medical societies that “are in agreement” with the IDSA Lyme recommendations.
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Although Lyme disease responds to short courses of antibiotics, tick-borne Borrelia burgdorferi has been advanced by some as a frequent explanation for medically unexplained symptoms, and practitioners liberally prescribe nostrums in a belief that this eradicates suspected infection.
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This strange story begins with the disease's original characterization in the USA in the early 1970s, when a surprising number of children in Lyme and Old Lyme, Connecticut, were diagnosed as having juvenile rheumatoid arthritis.
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An HBOT registry for Lyme disease and CLD would be an important tool to better understand the number of patients treated and whether or not HBOT has a beneficial effect on this puzzling and controversial condition.
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- 2015
A number of host cytokines were up- or down-regulated in tissues of both shame- and antibiotic-treated mice in the absence of histopathology, indicating a lack of host response to the presence of antimicrobial tolerant/resistant spirochetes.
Persistence of Non-Cultivable Borrelia burgdorferi Following Antibiotic Treatment : Critical Need for Further Research
- Medicine
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- MedicineEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
- 2011
Despite improvements in prevention, diagnosis and treatment, Lyme borreliosis (LB) is still the most common arthropod-borne disease in temperate regions of the northern hemisphere, with risk of…
Is It Possible to Make a Correct Diagnosis of Lyme Disease on Symptoms Alone? Review of Key Issues and Public Health Implications.
- MedicineThe American journal of medicine
- 2019
LYME DISEASE AND RELAPSING FEVER SPIROCHETES
- Biology
- 2020
This chapter reviews currently available technologies for live imaging that have been used on B. burgdorferi and that have revealed significant new findings and discusses the methodologies to be described here, which are highly varied, as are the processes studied and the resulting knowledge gained.
References
SHOWING 1-10 OF 24 REFERENCES
“Chronic Lyme” and other medically unexplained syndromes
- MedicineFASEB journal : official publication of the Federation of American Societies for Experimental Biology
- 2007
Last fall, Lyme disease, a tick-borne borreliosis, made headlines in the business world: “Lyme Disease Guidelines Focus of Antitrust Probe,” the attorney general of Connecticut threatened to invoke anti-trust laws against The Infectious Diseases Society of America, which issued a set of evidencebased guidelines.
The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America.
- MedicineClinical infectious diseases : an official publication of the Infectious Diseases Society of America
- 2006
These updated guidelines replace the previous treatment guidelines published in 2000 and list the doses and durations of antimicrobial therapy recommended for treatment and prevention of Lyme disease and provide a partial list of therapies to be avoided.
Misconceptions about Lyme Disease: Confusions Hiding behind Ill-Chosen Terminology
- MedicineAnnals of Internal Medicine
- 2002
A review of the terminology contributing to confusion about Lyme disease is needed, finding that chronic is a common clinical diagnosis in some geographic areas and is based on thinking that is at odds with scientifically validated findings.
Science, politics, and values: the politicization of professional practice guidelines.
- MedicineJAMA
- 2009
This case exemplifies the politicization of health policy and confuses the relative spheres inhabited by normative discourse and science, as medical science, and the patients who depend on it, is too important for political distortion.
Study and treatment of post Lyme disease (STOP-LD)
- Medicine, PsychologyNeurology
- 2003
Ceftriaxone therapy in patients with PLS with severe fatigue was associated with an improvement in fatigue but not with cognitive function or an experimental laboratory measure of infection in this study.
Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease.
- Medicine, PsychologyThe New England journal of medicine
- 2001
There is considerable impairment of health-related quality of life among patients with persistent symptoms despite previous antibiotic treatment for acute Lyme disease, and treatment with intravenous and oral antibiotics for 90 days did not improve symptoms more than placebo.
PRACTICE PARAMETER: TREATMENT OF NERVOUS SYSTEM LYME DISEASE (AN EVIDENCE-BASED REVIEW): REPORT OF THE QUALITY STANDARDS SUBCOMMITTEE OF THE AMERICAN ACADEMY OF NEUROLOGY
- MedicineNeurology
- 2008
A serious ethical problem is pointed out with the recently adopted Lyme disease treatment guidelines of the American Academy of Neurology and it is unacceptable to repackage the beleaguered guidelines of another medical society and allow overlapping panel members with clear conflicts of interest to control the process.
A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy
- Medicine, PsychologyNeurology
- 2008
I ceftriaxone therapy results in short-term cognitive improvement for patients with posttreatment Lyme encephalopathy, but relapse in cognition occurs after the antibiotic is discontinued, and treatment strategies that result in sustained cognitive improvement are needed.
The laboratory diagnosis of Lyme borreliosis: Guidelines from the Canadian Public Health Laboratory Network.
- MedicineThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
- 2007
The Canadian Public Health Laboratory Network has developed the present guidelines to assist physicians in assessing patients for Lyme borreliosis, and to help guide the choice and interpretation of laboratory testing.