Chronic Lithium Treatment Decreases Neuronal Activity in the Nucleus Accumbens and Cingulate Cortex of the Rat

Although the efficacy of lithium as a mood stabilizer is well documented, the mechanism of its therapeutic effect associated with prolonged treatment remains unknown. Identifying discrete brain regions and neural pathways that are functionally altered following long-term lithium treatment is central to elucidating a psychotherapeutic mechanism. We have used… CONTINUE READING