Chronic Jet Lag Produces Cognitive Deficits

@article{Cho2000ChronicJL,
  title={Chronic Jet Lag Produces Cognitive Deficits},
  author={Kwangwook Cho and Abdelkader Ennaceur and Jon C. Cole and Chang Kook Suh},
  journal={The Journal of Neuroscience},
  year={2000},
  volume={20},
  pages={RC66 - RC66}
}
Traveling across time zones causes disruption to the normal circadian rhythms and social schedules because of travelers' shift in time. As the endogenous circadian timing system adapts slowly to new time cues, the phase relationship between biological rhythms and external time cues are out of synchronization for a period of time. This disturbance of circadian rhythms has been shown to impair physical and psychological health (Winget et al., 1984). To test the effects of repeated jet lag on… 

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References

SHOWING 1-10 OF 23 REFERENCES

Effects of 10 h time zone changes on female flight attendants' circadian rhythms of body temperature, alertness, and visual search.

The duration of the de- and resynchronization process of the flight attendants' circadian rhythms is on the average longer than 9 days during and after round flights over ten time zones and the mean alertness of the subject can be predicted with considerable accuracy using the mathematical model.

A review of human physiological and performance changes associated with desynchronosis of biological rhythms.

This review discusses the effects, in the aerospace environment, of alterations in approximately 24-h periodicities (circadian rhythms) upon physiological and psychological functions and possible

Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol.

There are marked gender-specific effects of aging on the levels and diurnal variation of human adrenocorticotropic activity, consistent with the hypothesis of the "wear and tear" of lifelong exposure to stress.

Decreased memory performance in healthy humans induced by stress-level cortisol treatment.

Several days of exposure to cortisol at doses and plasma concentrations associated with physical and psychological stress in humans can-similar to pharmacological GC treatment-reversibly decrease specific elements of memory performance in otherwise healthy individuals.

Basal cortisol levels and cognitive deficits in human aging

Impaired cognitive performance was associated with recent evidence of hypothalamic-pituitary-adrenal (HPA) dysregulation and elevated basal cortisol levels and was consistent with recent animal studies showing the existence of subpopulations of aged rats that differ in HPA activity and cognitive performance.

Short-term total sleep deprivations does not selectively impair higher cortical functioning.

Performance on an intelligence test, a test of sustained attention and tests designed to measure higher cortical function were compared in a group of 29 subjects who underwent 34-36 hours of continuous sleep deprivation and 32 normal sleeping control subjects and no significant group performance differences in the hypothesized direction were noted.

Stress-induced declarative memory impairment in healthy elderly subjects: relationship to cortisol reactivity.

The results show that the cortisol response to anticipation of stress and to stress in the elderly specifically affects those memory functions that are dependent on hippocampal activity, and suggest that an altered cortisol responsivity to acute and/or chronic stress, with its detrimental effects on memory, could be an important factor explaining the genesis of memory deficits in aged populations.

Stress and cognitive function

Cortisol levels during human aging predict hippocampal atrophy and memory deficits

It is demonstrated that aged humans with significant prolonged cortisol elevations showed reduced hippocampal volume and deficits in hippocampus-dependent memory tasks compared to normal-cortisol controls, and the degree of hippocampal atrophy correlated strongly with both the degree and current basal cortisol levels.

Age-Related Changes in Regional Cerebral Blood Flow during Working Memory for Faces

Differences elsewhere in the brain suggest that different strategies or cognitive processes are used by the elderly to maintain memory representations over short periods of time.