• Corpus ID: 89130000

Chronic Intermittent Hypoxia Enhances Carotid Body Chemosensory Responses to Acute Hypoxia

@inproceedings{Celular2006ChronicIH,
  title={Chronic Intermittent Hypoxia Enhances Carotid Body Chemosensory Responses to Acute Hypoxia},
  author={Laboratorio de Fisiologia Celular and Oratorio de Neurobiolog and Facultad de Ciencias Biol{\'o}gicas},
  year={2006}
}

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TLDR
It is hypothesized that afferent information from the peripheral chemoreceptors may be necessary to produce diurnal blood pressure elevation in this Hypoxia model, a rat model that responds to repetitive episodic hypoxia with an increase in diurnal systemic blood pressure.
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Mammals experience episodic hypoxia, often in life, even perhaps more so than sustained hypoxiania that occurs in situations like high altitude.
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This mini-review summarizes the importance of peripheral chemoreceptor reflexes in various physiological and pathophysiological conditions and proposes a strategy to prevent the progression of the morbidity associated with these diseases.
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TLDR
It is demonstrated that acute, brief EH elicits LTF in respiratory motor output and prior conditioning with CIH, but not with comparable, cumulative duration of sustained hypoxia, augments LTF elicited by acute EH; and O(2)(-)* radical scavenger prevents CIH-induced potentiation of LTF of respiration.
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TLDR
It is demonstrated that CIH enhanced ventilatory LTF in conscious, freely behaving rats in two ways: 1) a previously ineffective protocol induced LTF; and 2) LTF magnitude was increased and LTF duration prolonged, and this CIH effect on LTF persisted for at least 3 days.
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TLDR
OSA is associated with a selective potentiation of autonomic, hemodynamic, and ventilatory responses to peripheral chemoreceptor activation by hypoxia, and this mechanism is implicated in increased cardiovascular stress in patients with obstructive sleep apnea.
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TLDR
Cardiovascular variability is altered in patients with OSA, evident even in the absence of hypertension, heart failure, or other disease states and may be linked to the severity of OSA.
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