Chronic Inhibition of PDE5 Limits Pro-Inflammatory Monocyte-Macrophage Polarization in Streptozotocin-Induced Diabetic Mice

@inproceedings{Venneri2015ChronicIO,
  title={Chronic Inhibition of PDE5 Limits Pro-Inflammatory Monocyte-Macrophage Polarization in Streptozotocin-Induced Diabetic Mice},
  author={Mary A Venneri and E Giannetta and Giuseppe Panio and Rita De Gaetano and Daniele Gianfrilli and Riccardo Pofi and Silvia Masciarelli and Francesco Fazi and Manuela Pellegrini and Andrea Lenzi and Fabio Naro and Andrea M. Isidori},
  booktitle={PloS one},
  year={2015}
}
Diabetes mellitus is characterized by changes in endothelial cells that alter monocyte recruitment, increase classic (M1-type) tissue macrophage infiltration and lead to self-sustained inflammation. Our and other groups recently showed that chronic inhibition of phosphodiesterase-5 (PDE5i) affects circulating cytokine levels in patients with diabetes; whether PDE5i also affects circulating monocytes and tissue inflammatory cell infiltration remains to be established. Using murine streptozotocin… CONTINUE READING

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