Chronic Ingestion of Advanced Glycation End Products Induces Degenerative Spinal Changes and Hypertrophy in Aging Pre-Diabetic Mice

@inproceedings{IllienJnger2015ChronicIO,
  title={Chronic Ingestion of Advanced Glycation End Products Induces Degenerative Spinal Changes and Hypertrophy in Aging Pre-Diabetic Mice},
  author={Svenja Illien-J{\"u}nger and Young Lu and Sheeraz Al Qureshi and Andrew C. Hecht and Weijing Cai and Helen Vlassara and Gary E. Striker and James C Iatridis},
  booktitle={PloS one},
  year={2015}
}
Intervertebral disc (IVD) degeneration and pathological spinal changes are major causes of back pain, which is the top cause of global disability. Obese and diabetic individuals are at increased risk for back pain and musculoskeletal complications. Modern diets contain high levels of advanced glycation end products (AGEs), cyto-toxic components which are known contributors to obesity, diabetes and accelerated aging pathologies. There is little information about potential effects of AGE rich… CONTINUE READING
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