Chronic Inflammatory IFN-g Signaling Suppresses Hepatocarcinogenesis in Mice by Sensitizing Hepatocytes for Apoptosis

@inproceedings{Schrader2011ChronicII,
  title={Chronic Inflammatory IFN-g Signaling Suppresses Hepatocarcinogenesis in Mice by Sensitizing Hepatocytes for Apoptosis},
  author={O Schrader and Stefan Zander and Antonella Carambia and Juliane Buchkremer and Samuel Huber and Kurt Reifenberg and Ken-ichi Yamamura and Peter Schirmacher and Ansgar Wilhelm Lohse and Johannes Herkel},
  year={2011}
}
Chronic liver inflammation is a critical component of hepatocarcinogenesis. Indeed, inflammatory mediators are believed to promote liver cancer by upholding compensatory proliferation of hepatocytes in response to tissue damage. However, inflammation can also mediate the depletion of malignant cells, but the difference between tumor-suppressive and tumor… CONTINUE READING