Chronic In Vitro Exposure to 3′-Azido-2′, 3′-Dideoxythymidine Induces Senescence and Apoptosis and Reduces Tumorigenicity of Metastatic Mouse Mammary Tumor Cells

@article{Tejera2001ChronicIV,
  title={Chronic In Vitro Exposure to 3′-Azido-2′, 3′-Dideoxythymidine Induces Senescence and Apoptosis and Reduces Tumorigenicity of Metastatic Mouse Mammary Tumor Cells},
  author={Agueda M. Tejera and D. fnL{\'o}pez Alonso and Daniel Eduardo G{\'o}mez and Ofelia A. Olivero},
  journal={Breast Cancer Research and Treatment},
  year={2001},
  volume={65},
  pages={93-99}
}
Normal cells in culture divide a certain amount of times and undergo a process termed replicative senescence. Telomere loss is thought to control entry into senescence. Activation of telomerase in tumors bypasses cellular senescence and is thus a requirement for tumor progression. We reported previously the preferential incorporation of 3′-azido-2′, 3′-dideoxythymidine (AZT) in telomeric sequences of immortalized cells in culture. In this work, we have investigated the effects of chronic in… CONTINUE READING
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Pogo BG-T: Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by 3′azido-3′- deoxythymidine

  • SM Melana, JF Holland
  • Clin Cancer Res
  • 1998
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