Aim: The aim of this study is to report on the reduction of breast cancer-related chest lymphedema associated with lymphatic hypertension and pain using Manual Lymphatic Therapy. Case report: We report on the case of a 52-year-old female patient, who developed breast and chest edema in November 2014 following breast reconstruction surgery performed immediately after mastectomy. The patient reported that she was submitted to 20 weekly chemotherapy sessions. She arrived at the Clinica Godoy in Sao Jose do Rio Preto to treat lymphedema in August 2015. The patient stated that she had noted the edema after surgery in the region of breast implant, and pain (analog scale 7) that was uncomfortable when she laid down at night to sleep and limited her daily life activities and work. Daily sessions of an adapted Manual Lymphatic Therapy technique (Godoy & Godoy method) for ten days was proposed. Bioimpedance was used at the start and end of treatment to evaluate the edema. Conclusion: The adaptation to lymphatic therapy significantly reduced the edema and consequently the pain without risking further impairment of the lymphatic system.