Chronic GBR 12909 administration differentially alters prodynorphin gene expression compared to cocaine.

@article{Romualdi2001ChronicG1,
  title={Chronic GBR 12909 administration differentially alters prodynorphin gene expression compared to cocaine.},
  author={Patrizia Romualdi and C D'addario and Simona Ferri and Brian M. Cox and S. E. Izenwasser},
  journal={European journal of pharmacology},
  year={2001},
  volume={413 2-3},
  pages={207-12}
}
The effect of the selective dopamine uptake inhibitor 1-[2-[bis(4-flourophenyl)methoxy]ethyl]-4-[3-phenylpropyl]piperazine dihydrochloride (GBR 12909) was examined on prodynorphin gene expression. GBR 12909 or vehicle was continuously infused for 7 days via osmotic minipump, or injected daily into male rats. Both continuous infusions and daily injections of GBR 12909 produced significant decreases in prodynorphin expression in the hypothalamus (37% and 31% decreases, respectively). There were… CONTINUE READING