Chronic Exposure to Nicotine Is Associated with Reduced Reward-Related Activity in the Striatum but not the Midbrain

@article{Rose2012ChronicET,
  title={Chronic Exposure to Nicotine Is Associated with Reduced Reward-Related Activity in the Striatum but not the Midbrain},
  author={Emma Jane Rose and Thomas J. Ross and Betty Jo Salmeron and Mary Lee and Elliot A. Stein},
  journal={Biological Psychiatry},
  year={2012},
  volume={71},
  pages={206-213}
}
  • Emma Jane Rose, Thomas J. Ross, +2 authors Elliot A. Stein
  • Published in Biological Psychiatry 2012
  • Psychology, Medicine
  • BACKGROUND The reinforcing effects of nicotine are mediated by brain regions that also support temporal difference error (TDE) processing; yet, the impact of nicotine on TDE is undetermined. METHODS Dependent smokers (n = 21) and matched control subjects (n = 21) were trained to associate a juice reward with a visual cue in a classical conditioning paradigm. Subjects subsequently underwent functional magnetic resonance imaging sessions in which they were exposed to trials where they either… CONTINUE READING

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