Chronic Ethanol Increases Lipopolysaccharide-stimulated Egr-1 Expression in RAW 264.7 Macrophages

  title={Chronic Ethanol Increases Lipopolysaccharide-stimulated Egr-1 Expression in RAW 264.7 Macrophages},
  author={L. Shi and R. Kishore and M. McMullen and L. Nagy},
  journal={The Journal of Biological Chemistry},
  pages={14777 - 14785}
  • L. Shi, R. Kishore, +1 author L. Nagy
  • Published 2002
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • Increased production of tumor necrosis factor α (TNFα) is associated with the development of alcoholic liver disease. Culture of RAW264.7 macrophages with 25 mm ethanol for 48 h increased lipopolysaccharide (LPS)-stimulated accumulation of tumor necrosis factor α (TNFα) peptide and mRNA by 2-fold. We investigated whether chronic ethanol-induced increases in the DNA binding and/or promoter activity of the key transcription factors regulating LPS-stimulated TNFα promoter activity contribute to… CONTINUE READING
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