Chronic Ethanol Consumption and Generation of Etheno-DNA Adducts in Cancer-Prone Tissues.

@article{Peccerella2018ChronicEC,
  title={Chronic Ethanol Consumption and Generation of Etheno-DNA Adducts in Cancer-Prone Tissues.},
  author={Teresa Peccerella and Tatjana Arslic-Schmitt and S. Mueller and Kirstin-Berit Linhart and D. Seth and H. Bartsch and H. Seitz},
  journal={Advances in experimental medicine and biology},
  year={2018},
  volume={1032},
  pages={
          81-92
        }
}
  • Teresa Peccerella, Tatjana Arslic-Schmitt, +4 authors H. Seitz
  • Published 2018
  • Chemistry, Medicine
  • Advances in experimental medicine and biology
  • Chronic ethanol consumption is a risk factor for several human cancers. A variety of mechanisms may contribute to this carcinogenic effect of alcohol including oxidative stress with the generation of reactive oxygen species (ROS), formed via inflammatory pathways or as byproducts of ethanol oxidation through cytochrome P4502E1 (CYP2E1). ROS may lead to lipidperoxidation (LPO) resulting in LPO-products such as 4-hydoxynonenal (4-HNE) or malondialdehyde. These compounds can react with DNA bases… CONTINUE READING
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    References

    SHOWING 1-10 OF 56 REFERENCES
    Keynote address: exocyclic adducts as new risk markers for DNA damage in man.
    • H. Bartsch
    • Medicine, Chemistry
    • IARC scientific publications
    • 1999
    • 48