Chronic ETA receptor blockade attenuates cardiac hypertrophy independently of blood pressure effects in renovascular hypertensive rats.

@article{Ehmke1999ChronicER,
  title={Chronic ETA receptor blockade attenuates cardiac hypertrophy independently of blood pressure effects in renovascular hypertensive rats.},
  author={Heimo Ehmke and Joerg Faulhaber and Klaus Muenter and Michael Kirchengast and Rudolf Josef Wiesner},
  journal={Hypertension},
  year={1999},
  volume={33 4},
  pages={954-60}
}
In isolated cardiac myocytes, the direct effects of angiotensin II on cellular growth and gene expression were shown to be mediated by endothelin via the endothelin subtype A (ETA) receptor. To determine whether this pathway is also involved in the cardiovascular adaptations to a chronic activation of the renin-angiotensin system in vivo, the effects of a selective ETA receptor antagonist (LU 127043) were investigated in adult rats with renal artery stenosis. Four groups of rats (n=107) were… CONTINUE READING

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