Chronic Dry Eye Disease is Principally Mediated by Effector Memory Th17 Cells

  title={Chronic Dry Eye Disease is Principally Mediated by Effector Memory Th17 Cells},
  author={Yihe Chen and Sunil K Chauhan and Hyun Soo Lee and Daniel R. Saban and Reza Dana},
  booktitle={Mucosal Immunology},
Recent experimental and clinical data suggest that there is a link between dry eye disease (DED) and T-cell-mediated immunity. However, whether these immune responses are a consequence or cause of ocular surface inflammation remains to be determined. Thus far, only models of acute DED have been used to derive experimental data. This is in contrast to clinical DED which usually presents as a chronic disease. In the present study, using a murine model of chronic DED, it was established that the… CONTINUE READING


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