Chronic Dietary Exposure to a Low-Dose Mixture of Genistein and Vinclozolin Modifies the Reproductive Axis, Testis Transcriptome, and Fertility

@inproceedings{Eustache2009ChronicDE,
  title={Chronic Dietary Exposure to a Low-Dose Mixture of Genistein and Vinclozolin Modifies the Reproductive Axis, Testis Transcriptome, and Fertility},
  author={Florence M Eustache and Françoise Mondon and Marie Chantal Canivenc-Lavier and Corinne Lesaffre and Yvonne Fulla and Raymond Berg{\`e}s and Jean Pierre Cravedi and Daniel Vaiman and Jacques Auger},
  booktitle={Environmental health perspectives},
  year={2009}
}
BACKGROUND The reproductive consequences and mechanisms of action of chronic exposure to low-dose endocrine disruptors are poorly understood. OBJECTIVE We assessed the effects of a continuous, low-dose exposure to a phytoestrogen (genistein) and/or an antiandrogenic food contaminant (vinclozolin) on the male reproductive tract and fertility. METHODS Male rats were exposed by gavage to genistein and vinclozolin from conception to adulthood, alone or in combination, at low doses (1 mg/kg/day… CONTINUE READING