Chronic Dietary Administration of the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG) Inhibits the Growth of Implanted Ehrlich’s Ascites Tumor in Mice

@inproceedings{Singh2015ChronicDA,
  title={Chronic Dietary Administration of the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG) Inhibits the Growth of Implanted Ehrlich’s Ascites Tumor in Mice},
  author={Saurabh P. Singh and Sanjay K Pandey and Anant Narayan Bhatt and Richa Singh Chaudhary and Vikas Bhuria and Namita Kalra and Ravi Mukundkumar Soni and Bal Gangadhar Roy and Daman Saluja and B S Dwarakanath and Chunyue Huang},
  booktitle={PloS one},
  year={2015}
}
BACKGROUND Dietary energy restriction (DER) has been well established as a potent anticancer strategy. Non-adoption of restricted diet for an extended period has limited its practical implementation in humans with a compelling need to develop agents that mimic effects similar to DER, without reduction in actual dietary intake. Glycolytic inhibitor, 2-deoxy-D-glucose (2-DG), has recently been shown to possess potential as an energy restriction mimetic agent (ERMA). In the present study we… CONTINUE READING

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