Chronic Cocaine-Induced H3 Acetylation and Transcriptional Activation of CaMKIIα in the Nucleus Accumbens Is Critical for Motivation for Drug Reinforcement

@article{Wang2010ChronicCH,
  title={Chronic Cocaine-Induced H3 Acetylation and Transcriptional Activation of CaMKIIα in the Nucleus Accumbens Is Critical for Motivation for Drug Reinforcement},
  author={Lei Wang and Zhigang Lv and Zhaoyang Hu and Jian Zhong Sheng and Bin Hui and Jie Sun and Lan Ma},
  journal={Neuropsychopharmacology},
  year={2010},
  volume={35},
  pages={913-928}
}
The regulation of gene expression in the brain reward regions is known to contribute to the pathogenesis and persistence of drug addiction. Increasing evidence suggests that the regulation of gene transcription is mediated by epigenetic mechanisms that alter the chromatin structure at specific gene promoters. To better understand the involvement of epigenetic regulation in drug reinforcement properties, rats were subjected to cocaine self-administration paradigm. Daily histone deacetylase (HDAC… CONTINUE READING

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