Chronic Cigarette Smoke Causes Oxidative Damage and Apoptosis to Retinal Pigmented Epithelial Cells in Mice

@article{Fujihara2008ChronicCS,
  title={Chronic Cigarette Smoke Causes Oxidative Damage and Apoptosis to Retinal Pigmented Epithelial Cells in Mice},
  author={Masashi Fujihara and Norihiro Nagai and Thomas Sussan and Shyam S. Biswal and James T. Handa},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={564 - 572}
}
The purpose of this study was to determine whether mice exposed to chronic cigarette smoke develop features of early age-related macular degeneration (AMD). Two month old C57Bl6 mice were exposed to either filtered air or cigarette smoke in a smoking chamber for 5 h/day, 5 days/week for 6 months. Eyes were fixed in 2.5% glutaraldehyde/2% paraformaldehyde and examined for ultrastructural changes by transmission electron microscopy. The contralateral eye was fixed in 2% paraformaldehyde and… CONTINUE READING

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