Chronic Chagas' disease in the mouse: contractile response of the isolated myocardium.


The effects of different pharmacological agents on the isometric developed tension (IDT) of right ventricles isolated from chronic chagasic C3HS mice were studied. The IDT in ventricles of chagasic animals was lower than in ventricles of normal mice (P less than 0.01). Chagasic ventricles exhibited hyperreactivity to norepinephrine but not to epinephrine… (More)


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