Chronic Chagas' disease cardiomyopathy patients display an increased IFN-gamma response to Trypanosoma cruzi infection.

@article{Abel2001ChronicCD,
  title={Chronic Chagas' disease cardiomyopathy patients display an increased IFN-gamma response to Trypanosoma cruzi infection.},
  author={L{\'u}cia Cristina Jamli Abel and Luiz Vicente Rizzo and B{\'a}rbara Ianni and Felipe Albuquerque and Fernando F Bacal and Dirceu Carrara and Edmar Alcides Bocchi and Henrique Couto Teixeira and Charles Mady and Jorge Agle Kalil and Edecio Cunha-Neto},
  journal={Journal of autoimmunity},
  year={2001},
  volume={17 1},
  pages={99-107}
}
One-third of all Trypanosoma cruzi -infected patients eventually develop chronic Chagas' disease cardiomyopathy (CCC), a particularly lethal inflammatory dilated cardiomyopathy, where parasites are scarce and heart-infiltrating mononuclear cells seem to be the effectors of tissue damage. Since T. cruzi is a major inducer of interleukin-12 production, the role of inflammatory cytokines in the pathogenesis of CCC was investigated. We assayed cytokine production by peripheral blood mononuclear… CONTINUE READING
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