Chronic CRP-exposure inhibits VEGF-induced endothelial cell migration.

  title={Chronic CRP-exposure inhibits VEGF-induced endothelial cell migration.},
  author={Christopher Schneeweis and Michael Graefe and Anne Bungenstock and Chantel Spencer-H{\"a}nsch and Eckart Fleck and Stephan Goetze},
  journal={Journal of atherosclerosis and thrombosis},
  volume={17 2},
UNLABELLED C-reactive protein (CRP) is a pluripotent mediator of inflammation and is present at sites of vascular injury and in atherosclerotic lesions. CRP stimulates endothelial cell adhesion molecule expression and monocyte migration, thereby contributing to the development and progression of vascular lesion formation. In addition, chronic exposure to CRP is known to inhibit angiogenesis and endothelial cell (EC) proliferation. AIM Whether CRP also affects EC migration, however, has yet to… CONTINUE READING