Chronic CMV infection in older women: Longitudinal comparisons of CMV DNA in peripheral monocytes, anti-CMV IgG titers, serum IL-6 levels, and CMV pp65 (NLV)-specific CD8<ce:sup loc=post>+</ce:sup> T-cell frequencies with twelve year follow-up

@article{Li2014ChronicCI,
  title={Chronic CMV infection in older women: Longitudinal comparisons of CMV DNA in peripheral monocytes, anti-CMV IgG titers, serum IL-6 levels, and CMV pp65 (NLV)-specific CD8<ce:sup loc=post>+</ce:sup> T-cell frequencies with twelve year follow-up},
  author={Huifen Li and Peter Chang-Yi Weng and Kevin M Najarro and Qian-Li Xue and Sean X Leng},
  journal={Experimental Gerontology},
  year={2014},
  volume={54},
  pages={84-89}
}
Chronic cytomegalovirus (CMV) infection may contribute significantly to T-cell immunosenescence, chronic inflammation, and adverse health outcomes in older adults. Recent studies suggest detectable CMV DNA in peripheral monocytes as a better indicator for this persistent viral infection than anti-CMV IgG serology. Here, we conducted longitudinal comparisons of anti-CMV IgG titers, CMV DNA in the peripheral monocytes, serum IL-6 levels, and CMV pp65 (NLV)-specific CD8(+) T-cell frequencies in… CONTINUE READING
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Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly

  • S. R. Hadrup, J. Strindhall, T Kollgaard
  • J. Immunol
  • 2006
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