Chronic Brucellosis Patients Retain Low Frequency of CD4+ T-Lymphocytes Expressing CD25 and CD28 after Escherichia coli LPS Stimulation of PHA-Cultured PBMCs

@article{Skendros2008ChronicBP,
  title={Chronic Brucellosis Patients Retain Low Frequency of  CD4+ T-Lymphocytes Expressing CD25 and CD28 after Escherichia  coli LPS Stimulation of PHA-Cultured PBMCs},
  author={Panagiotis Skendros and Alexandros Sarantopoulos and Konstantinos Tselios and Panagiota Boura},
  journal={Clinical and Developmental Immunology},
  year={2008},
  volume={2008},
  pages={2325 - 2336}
}
Chronic brucellosis patients display a defective Th1 response to PHA. We have previously shown that heat-killed B. abortus (HKBA) can downregulate the PHA-induced increase of CD4+/CD25+ and CD14+/CD80+ cells of brucellosis patients. In the present study, we investigate the effect of E. coli LPS, as a potent stimulant of monocytes and autologous T-lymphocytes, on the PHA-cultured PBMCs of the same groups of patients. Thirteen acute brucellosis (AB) patients, 22 chronic brucellosis (CB) patients… CONTINUE READING
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Brucellosis

  • G. Pappas, N. Akritidis, M. Bosilkovski, E. Tsianos
  • The New England Journal of Medicine, vol. 352, no…
  • 2005
Highly Influential
4 Excerpts

Cytokine regulation and establishment of chronicity in brucellosis

  • E. Zacharioudaki, P. Boura, I. Kountouras, P. Skendros, N. Lefkos
  • Immunology Letters, vol. 87, p. 51, 2003…
  • 2003
Highly Influential
5 Excerpts

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