Chronic BDNF deficiency leads to an age-dependent impairment in spatial learning

@article{Petzold2015ChronicBD,
  title={Chronic BDNF deficiency leads to an age-dependent impairment in spatial learning},
  author={Anne Petzold and Laura Psotta and Tanja Brigadski and Thomas Endres and Volkmar Lessmann},
  journal={Neurobiology of Learning and Memory},
  year={2015},
  volume={120},
  pages={52-60}
}
Brain-derived neurotrophic factor (BDNF) is a crucial mediator of neural plasticity and, consequently, of memory formation. In hippocampus-dependent learning tasks BDNF also seems to play an essential role. However, there are conflicting results concerning the spatial learning ability of aging BDNF(+/-) mice in the Morris water maze paradigm. To evaluate the effect of chronic BDNF deficiency in the hippocampus on spatial learning throughout life, we conducted a comprehensive study to test… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

BDNF controls object recognition memory reconsolidation

Neurobiology of Learning and Memory • 2017
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…