Chronic Arsenic Exposure and Angiogenesis in Human Bronchial Epithelial Cells via the ROS/miR-199a-5p/HIF-1α/COX-2 Pathway

@inproceedings{He2014ChronicAE,
  title={Chronic Arsenic Exposure and Angiogenesis in Human Bronchial Epithelial Cells via the ROS/miR-199a-5p/HIF-1α/COX-2 Pathway},
  author={Jun He and Min Wang and Yue Jiang and Qiudan Chen and Shaohua Xu and Qing Xu and Bing-hua Jiang and Ling-zhi Liu},
  booktitle={Environmental health perspectives},
  year={2014}
}
BACKGROUND Environmental and occupational exposure to arsenic is a major public health concern. Although it has been identified as a human carcinogen, the molecular mechanism underlying the arsenic-induced carcinogenesis is not well understood. OBJECTIVES We aimed to determine the role and mechanisms of miRNAs in arsenic-induced tumor angiogenesis and tumor growth. METHODS We utilized an in vitro model in which human lung epithelial BEAS-2B cells were transformed through long-term exposure… CONTINUE READING
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