Chronic Antipsychotic Treatment in the Rat – Effects on Brain Interleukin-8 and Kynurenic Acid

@inproceedings{Larsson2015ChronicAT,
  title={Chronic Antipsychotic Treatment in the Rat – Effects on Brain Interleukin-8 and Kynurenic Acid},
  author={Markus K. Larsson and Lilly Schwieler and Michel Goiny and S Erhardt and G{\"o}ran Engberg},
  booktitle={International journal of tryptophan research : IJTR},
  year={2015}
}
Schizophrenia is associated with activation of the brain immune system as reflected by increased brain levels of kynurenic acid (KYNA) and proinflammatory cytokines. Although antipsychotic drugs have been used for decades in the treatment of the disease, potential effects of these drugs on brain immune signaling are not fully known. The aim of the present study is to investigate the effects of chronic treatment with antipsychotic drugs on brain levels of cytokines and KYNA. Rats were treated… CONTINUE READING
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