Chronic Anti-inflammatory Drug Therapy Inhibits Gel-Forming Mucin Production in a Murine Xenograft Model of Human Pseudomyxoma Peritonei

@article{Choudry2012ChronicAD,
  title={Chronic Anti-inflammatory Drug Therapy Inhibits Gel-Forming Mucin Production in a Murine Xenograft Model of Human Pseudomyxoma Peritonei},
  author={Haroon Asif Choudry and Arun Mavanur and BS MarkE.O’Malley and Herbert J. Zeh and Zong Sheng Guo and David L. Bartlett},
  journal={Annals of Surgical Oncology},
  year={2012},
  volume={19},
  pages={1402-1409}
}
Intraperitoneal accumulation of mucinous ascites in pseudomyxoma peritonei (PMP) promotes an inflammatory/fibrotic reaction that progresses to bowel obstruction and eventual patient demise. Cytokines and inflammation-associated transcription factor binding sites, such as glucocorticoid response elements and COX-2, regulate secretory mucin, specifically MUC2, production. We hypothesized that anti-inflammatory drugs targeting inflammation-associated pathways may reduce mucin production and… CONTINUE READING
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