Chronic Alcohol Exposure Differentially Alters One-Carbon Metabolism in Rat Liver and Brain.


BACKGROUND Epigenetic mechanisms such as DNA methylation play an important role in regulating the pathophysiology of alcoholism. Chronic alcohol exposure leads to behavioral changes as well as decreased expression of genes associated with synaptic plasticity. In the liver, it has been documented that chronic alcohol exposure impairs methionine synthase (Ms… (More)
DOI: 10.1111/acer.13382