Chronic Akt1 deficiency attenuates adverse remodeling and enhances angiogenesis after myocardial infarction.

Abstract

BACKGROUND Akt1 is a key signaling molecule in multiple cell types, including endothelial cells. Accordingly, Akt1 was proposed as a therapeutic target for ischemic injury in the context of myocardial infarction (MI). The aim of this study was to use multimodal in vivo imaging to investigate the impact of systemic Akt1 deficiency on cardiac function and… (More)
DOI: 10.1161/CIRCIMAGING.113.000828

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