Chronic Adolescent Exposure to Δ-9-Tetrahydrocannabinol in COMT Mutant Mice: Impact on Psychosis-Related and Other Phenotypes

@article{OTuathaigh2010ChronicAE,
  title={Chronic Adolescent Exposure to Δ-9-Tetrahydrocannabinol in COMT Mutant Mice: Impact on Psychosis-Related and Other Phenotypes},
  author={Colm M P O'Tuathaigh and Magdalena Hryniewiecka and Aine T Behan and Orna Tighe and Catherine Coughlan and Lieve Desbonnet and Mary Cannon and Maria Karayiorgou and Joseph A Gogos and David Richard Cotter and John L Waddington},
  journal={Neuropsychopharmacology},
  year={2010},
  volume={35},
  pages={2262-2273}
}
Cannabis use confers a two-fold increase in the risk for psychosis, with adolescent use conferring even greater risk. A high–low activity catechol-O-methyltransferase (COMT) polymorphism may modulate the effects of adolescent Δ-9-tetrahydrocannabinol (THC) exposure on the risk for adult psychosis. Mice with knockout of the COMT gene were treated chronically with THC (4.0 and 8.0 mg/kg over 20 days) during either adolescence (postnatal days (PDs) 32–52) or adulthood (PDs 70–90). The effects of… CONTINUE READING
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