Chronic Administration of Anacetrapib Is Associated With Accumulation in Adipose and Slow Elimination.

@article{Krishna2017ChronicAO,
  title={Chronic Administration of Anacetrapib Is Associated With Accumulation in Adipose and Slow Elimination.},
  author={Rajesh Krishna and Ferdous Gheyas and Yang Liu and David Hagen and Brienne Walker and Ajay Chawla and Jos{\'e}e C{\^o}t{\'e} and Robert O. Blaustein and David E. Gutstein},
  journal={Clinical pharmacology and therapeutics},
  year={2017},
  volume={102 5},
  pages={832-840}
}
Anacetrapib is a novel cholesteryl-ester transfer protein (CETP) inhibitor in late-stage clinical development, shown in preceding clinical trials to have residual pharmacological activity after prolonged washout after chronic dosing. Preclinical findings suggest that white adipose tissue is a potential depot and that accumulation into adipose tissue governs the long-term kinetics of anacetrapib in mice. A phase I study performed to test this hypothesis in humans revealed that plasma exposure… CONTINUE READING

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