Chronic 5-HT6 receptor modulation by E-6837 induces hypophagia and sustained weight loss in diet-induced obese rats.

@article{Fisas2006Chronic5R,
  title={Chronic 5-HT6 receptor modulation by E-6837 induces hypophagia and sustained weight loss in diet-induced obese rats.},
  author={Angels Fisas and Xavier Codony and Gonzalo Romero and Alberto Dordal and Jes{\'u}s Giraldo and Ramon Merc{\'e} and J{\"o}rg Holenz and Niels Vrang and Rikke Veggerby S\orensen and David J. Heal and Helmut Buschmann and Petrus Johan Pauwels},
  journal={British journal of pharmacology},
  year={2006},
  volume={148 7},
  pages={973-83}
}
E-6837 is a novel, selective and high-affinity 5-HT(6) receptor ligand (pK(i): 9.13) which in vitro demonstrates partial agonism at a presumably silent rat 5-HT(6) receptor and full agonism at a constitutively active human 5-HT(6) receptor by monitoring the cAMP signaling pathway.The effects of chronic treatment with E-6837 were determined in diet-induced obese (DIO)-rats on changes in body weight, food and water intake, plasma indices of comorbid risk factors, and weight regain on compound… CONTINUE READING

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