Chronic (−)-isoprenaline infusion down-regulates β1- and β2-adrenoceptors but does not transregulate muscarinic cholinoceptors in rat heart

@article{Matthews2004ChronicI,
  title={Chronic (−)-isoprenaline infusion down-regulates β1- and β2-adrenoceptors but does not transregulate muscarinic cholinoceptors in rat heart},
  author={Janine M. Matthews and Patrick H.J. Falckh and Peter Molenaar and Roger J Summers},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={353},
  pages={213-225}
}
Regulation of β-adrenoceptor (β-ar) subtypes and transregulation of muscarinic cholinoceptors (mAchr) was examined in regions of rat heart after chronic infusion of (−)-isoprenaline (450 μ/kg per hour) for 14 days. Following (−)-isoprenaline infusion systolic blood pressure was reduced for 10 days but then gradually returned to control levels, whereas heart rate was increased for 7 days before declining to a level significantly above control. Heart weight to body weight ratio was increased in… CONTINUE READING