Chronic, low-level exposure to diisopropylfluorophosphate causes protracted impairment of spatial navigation learning

@article{Prendergast1997ChronicLE,
  title={Chronic, low-level exposure to diisopropylfluorophosphate causes protracted impairment of spatial navigation learning},
  author={Mark A. Prendergast and Alvin V. Terry and Jerry J. Buccafusco},
  journal={Psychopharmacology},
  year={1997},
  volume={129},
  pages={183-191}
}
 Chronic, low-level exposure to cholinesterase inhibitor organophosphate (OP) insecticides or chemical warfare agents produces abnormalities in CNS acetylcholine (ACh) function, and in humans, may be associated with impaired cognitive function well after withdrawal from such exposure. The purpose of the present study was to identify the severity of impairment in spatial learning of rats following protracted withdrawal from chronic, low-level exposure to the OP agent diisopropylfluorophosphate… CONTINUE READING

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