Chronic, intermittent loading alters mechanosensitive channel characteristics in osteoblast-like cells.

@article{Duncan1994ChronicIL,
  title={Chronic, intermittent loading alters mechanosensitive channel characteristics in osteoblast-like cells.},
  author={R L Duncan and Keith A. Hruska},
  journal={The American journal of physiology},
  year={1994},
  volume={267 6 Pt 2},
  pages={F909-16}
}
The effects of chronic, intermittent strain on the mechanosensitive cation (SA-cat) channels in UMR-106.01 osteoblast-like osteosarcoma cells were studied using patch-clamp techniques. Chronically strained cells demonstrated significantly larger increases in whole cell conductance when subjected to additional mechanical strain than nonstrained controls (69.0 +/- 15.1 vs. 14.1 +/- 3.1%; P < 0.001). This increase could be blocked by the SA-cat channel inhibitor, gadolinium, and corresponded to a… CONTINUE READING

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